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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Curr Opin Immunol. 2011 Nov 24;23(6):721–731. doi: 10.1016/j.coi.2011.10.007

Figure 1. Receptor editing is a major mechanism of central tolerance in B cells.

Figure 1

Immature B cells in the bone marrow that encounter multivalent self antigens revert to the small pre-B stage, continue to rearrange κ and if necessary λ light chain genes and generate newly generated B cells that have a novel light chain that is no longer self-reactive. Immature B cells with novel light chains that are no longer part of a self-reactive B cell receptor, then migrate to the periphery as T1 B cells where they mature into newly generated IgM and IgD expressing recirculating T2 B cells and then into mature recirculating B cells.