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Fra-LI activity immunoreactivity in the PVN. HF rats had higher PVN levels of Fra-LI (black dots) immunoreactivity when compared with SHAM rats. Bilateral PVN infusions of SN50 for 4 weeks decreased Fra-LI expression in the PVN of HF rats. PVN infusions of SN50M for 4 weeks did not alter Fra-LI expression in the PVN of HF rats. *P<0.05 versus SHAM groups. †P<0.05 HF+PVN SN50 versus HF+PVN vehicle or HF+PVN SN50M.
