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Renal sympathetic nerve activity (RSNA) was increased in HF rats compared with SHAM rats. Treatment with bilateral PVN infusions of SN50 for 4 weeks decreased RSNA of HF rats. PVN infusions of SN50M for 4 weeks did not alter RSNA of HF rats. *P<0.05 versus SHAM groups. †P<0.05 HF+PVN SN50 versus HF+PVN vehicle or HF+PVN SN50M.
