Skip to main content
. Author manuscript; available in PMC: 2012 Oct 12.
Published in final edited form as: J Am Chem Soc. 2011 Sep 19;133(40):15803–15805. doi: 10.1021/ja2077137

Figure 1.

Figure 1

(a) Possible mechanism for the inactivation of PTP1B by H2O2-HCO3 −. (b) Treatment of PTP1B with H2O2-HCO3 − yields the oxidized, sulfenyl amide form of the enzyme. The structure of the oxidized enzyme was solved at 1.7 Å resolution (pdb code 3SME). The image shows a simulated annealing σA-weighted Fo-Fc omit map contoured at 3.0σ covering Cys215 and flanking residues.