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. Author manuscript; available in PMC: 2012 Jan 30.
Published in final edited form as: Pharmacol Res. 2010 Oct 8;63(1):23–29. doi: 10.1016/j.phrs.2010.09.007

Figure 2. LA treatment decreases mitochondrial ceramides.

Figure 2

Young and old rats were fed (R)-α-lipoic acid (LA; 0.2% [w/w]) or a control diet for two weeks. Mitochondria were isolated, lipids extracted and analyzed by LC-MS/MS. Total ceramide was increased in cardiac mitochondria from aged rats; LA restored ceramides to levels seen in young animals but resulted in no alteration of ceramide levels in young rats. Data represent the means ± SEM, n = 4; an asterisk (*) denotes a significant difference by Student's t-test between old and young control animals, p < 0.03.