TABLE 2.

Generalized Estimation Equation Modeling Analysis of Quadratic Age as a Predictor of MMSE Decline

	Estimation	SE	P
Age	−0.03	0.07	0.64
Sex*	−0.37	0.25	0.14
MMSE at baseline	0.79	0.05	<0.0001
Educ: <8 y*	−0.01	0.59	0.98
Educ: 8-12 y	0.15	0.30	0.61
Race*	0.90	0.45	0.05
CDR=0*	3.76	0.78	<0.0001
CDR=0.5*	1.88	0.83	0.02
Age×CDR (CDR=0)	0.007	0.07	0.92
Age×CDR (CDR=0.5)	0.11	0.08	0.14
Time	−1.85	0.21	<0.0001
Time×CDR (CDR=0)	1.63	0.22	<0.0001
Time×CDR (CDR=0.5)	1.54	0.26	<0.0001
Age×time	−0.007	0.03	0.78
Age×time×CDR (CDR=0)*	0.01	0.03	0.73
Age×time×CDR (CDR=0.5)*	−0.04	0.03	0.26
Squared age	−0.009	0.005	0.05
Squared age×CDR (CDR=0)*	0.009	0.005	0.08
Squared age×CDR (CDR=0.5)*	0.01	0.006	0.03
Time×squared age	0.003	0.002	0.07
Time×squared age×CDR (CDR=0)*	−0.003	0.002	0.13
Time×squared age×CDR (CDR=0.5)*	−0.005	0.002	0.02

^*Reference groups: sex: male; education: >12; race: White; CDR: CDR≥1; age×CDR: Age×(CDR ≥1); age×time×CDR interaction: CDR ≥1; squared age×CDR: CDR ≥1; time×squared age×CDR: CDR ≥1.

CDR indicates clinical dementia rating scale; Educ, education; MMSE, Mini Mental State Examination.