Table 1.

Flux control coefficients (FCCs) exerted by each reaction (see also figure 1 for a representation of the reaction) of the model on the glycolytic flux. (The second column gives the FCCs for the original parameter values given in Lambeth & Kushmerick (2002). The third and fourth columns show an estimation of the minimal and maximal values of the respective FCCs, when the V_max parameters are allowed to vary between half and double their original value. Correspondingly, columns five and six show the minimal and maximal values of the FCCs when the V_max parameters can vary between one-tenth and 10 times the original value. All minimum and maximum values were estimated using the ‘particle swarm’ optimization method in COPASI with settings ‘iteration limit’=150 and ‘swarm size’=30.)

		ranges of Vmax values
		0.5–2 times		0.1–10 times
	original	minimum	maximum	minimum	maximum
GP	−0.00027	−0.00060	−0.00005	−1.10392	0.04807
PGLM	0.0	0.0	0.0	−0.79746	0.00160
PGI	0.0	0.0	0.0	−0.11764	0.00017
PFK	−0.00001	−0.00007	0.00001	−0.76544	0.00284
ALD	0.0	0.0	0.0	0.0	0.14336
TPI	0.0	0.0	0.0	0.0	0.01432
GAPDH	0.0	0.0	0.0	0.0	1.45508
PGK	0.0	0.0	0.00001	0.0	0.76405
PGM	0.0	0.0	0.00001	0.0	0.61275
EN	0.0	0.0	0.00006	0.0	6.36451
PK	0.00026	0.00005	0.00139	0.0	1.36505
LDH	0.0	0.0	0.00001	0.0	0.12333
CK	0.0	0.0	0.0	0.0	0.0
ADK	0.0	0.0	0.0	0.0	0.0
ATPase	0.99971	0.99856	0.99994	−4.60501	1.00000
outflux	0.00029	0.00010	0.00062	0.0	1.25773