Table 2.

Sensitivity and specificity for Alzheimer’s disease before and after 1990^a

Authors	Clinical criteria	Number of cases	Sensitivity	Specificity
Before 1990
Todorov et al. (1975) [43]	Clinical diagnosis	726	43%	19%
Mölsa et al. (1985) [44]	Clinical diagnosis	58	71%	73%
Alafuzoff et al. (1987) [42]	DSM-III	55	63%	N/A
Wade et al. (1987) [30]	Standardized criteria	65	87%	78%
Joachim et al. (1988) [27]	Standardized criteria	150	87%	N/A
Boller et al. (1989) [23]	NINCDS-ADRDA	54	95%	33%
After 1990
Kukul et al. (1990) [28]	NINCDS-ADRDA	62	92%	65%
	DSM-III		76%	80%
Jellinger et al. (1990) [25]	NINCDS-ADRDA	675	85%	N/A
Burns et al. (1990) [22]	NINCDS-ADRDA	50	84%	N/A
Mendez et al. (1991) [29]	Clinical diagnosis	394	88%	N/A
Kazee et al. (1993) [33]	NINCDS-ADRDA	123	98%	69%
Galasko et al. (1994) [26]	NINCDS-ADRDA	151	86%	N/A
Blacker et al. (1994) [24]	NINCDS-ADRDA	60	81%	73%
Gearing et al. (1995) [34]	NINCDS-ADRDA	106	87%	N/A
Kosunen et al. (1996) [31]	NINCDS-ADRDA	56	96%	N/A
Jobst et al. (1998) [35]	NINCDS-ADRA	151	96%	61%
	DSM-III-R		51%	97%
Nagy et al. (1998) [36]	NINCDS-ADRA	73	98%	61%
Holmes et al. (1999) [39]	NINCDS-ADRDA	80b	66%	75%
Lim et al. (1999) [40]	NINCDS-ADRDA	134b	75%	54%
Massoud et al. (1999) [37]	NINCDS-ADRDA	63	98%	84%
Lopez et al. (2000) [13]	NINCDS-ADRDA	295	98%	88%
Petrovich et al. (2001) [41]	NINCDS-ADRDA	79b	87%	N/A
Hogervorst et al. (2003) [38]	NINCDS-ADRDA	204	92%	69%

N/A, not available.

^aClinicopathological studies with 50 or more patients.

^bPopulation-based study.