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. 2011 Dec 12;109(4):1299–1304. doi: 10.1073/pnas.1113540109

Fig. 1.

Fig. 1.

Oligodendrocytes exhibit striking diversity in the number and length of myelin internodes in vivo and in vitro. Brain section from (A) 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP)-GFP transgenic mouse where all oligodendrocytes are fluorescently labeled. (B) Transgenic mouse expressing maGFP in <1% of oligodendrocytes. (Scale bar: 1 mm.) (C) Individual oligodendrocytes from different CNS regions of the sparsely labeled mouse. Arrows indicate cell bodies. (Scale bar: 20 μm.) (D and E) Comparison of myelinogenic potential between CNS regions. (D) Individual oligodendrocytes from indicated regions form a varied number of myelin internodes. Error bars represent SD, and the middle line represents the average number of myelin internodes formed per oligodendrocyte for each indicated region. (E) Average length of myelin internodes formed by individual oligodendrocytes. Error bars represent SD of myelin internode lengths for each individual oligodendrocyte, and demonstrate the variation of length from single cells.