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. 2011 Dec 13;109(4):E197–E205. doi: 10.1073/pnas.1111098109

Fig. 6.

Fig. 6.

Microglial activation triggers glutamate release from astrocytes that acts on neuronal mGluRs. (A) Application of LPS in the presence of the mGluR5 antagonist MPEP prevented the EPSC frequency increase (n = 9, average ± SEM). Application of MPEP prevented the EPSC frequency increase by the P2Y1 agonist MRS2365 (n = 8, mean ± SEM). (B) Electron micrograph showing mGluR5 immunoreactivity (arrowheads; 10-nm gold particles) located on the postsynaptic (post) membrane (Left) and the presynaptic (pre) membrane (Right) juxtaposed to astrocytic processes (astro) identified by Glutamine Synthetase immunoreactivity (DAB accumulation) and outlined by dashed lines.