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Microglial activation exacerbates seizure activity. (A) Representative trace showing that microglial activation enhances the epileptiform bursting activity when neurons were recorded in medium with picrotoxin and low Mg2+. (B) Plots of the number of bursting events per 5 min for each cell (n = 7) before and after application of saline (black circles) or LPS (open circles; average bursting activity in 5 min ± SEM, ANOVA, *P < 0.05).
