FIGURE 3.

During Chlamydia replication, host LDs are actively transported into bacterial inclusions. Upper panel, Chlamydia RBs replicate within membrane-bound parasitophorous vacuoles. Bacterial Lda proteins are translocated into the host cytosol and bind to vacuole-associated LDs. Lda3 at the surface of LDs interacts with the bacterial protein IncX to transport cytosolic LDs into the inclusion. The LDs in the bacterial inclusions lack host ADRP, which may be required to enable degradation and utilization of host lipids (lower panel).