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. 2011 Nov 28;287(4):2353–2363. doi: 10.1074/jbc.M111.280974

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Exogenous FGF9 rescues Pitx2 expression in Tgfbr2^fl/fl;Wnt1-Cre mice during palatal development. A. Quantitative RT-PCR analysis of Pitx2 in primary MEPM cells of Tgfbr2^fl/fl control (open columns) and Tgfbr2^fl/fl;Wnt1-Cre (closed columns) mice after treatment (+) or no treatment (−) with FGF9 protein. *, p < 0.05. B, whole mount in situ hybridization after implantation of FGF9 or BSA control beads in the palate of Tgfbr2^fl/fl;Wnt1-Cre mice. The arrows indicate the increased expression of Pitx2 around FGF9 beads. C, section in situ hybridization for Pitx2 after implantation of FGF9 or BSA control beads in the palate of the Tgfbr2^fl/fl;Wnt1-Cre mice. The arrows indicate the increased expression of Pitx2 around FGF9 beads. Dotted lines, perimeter of the beads. D, quantitative RT-PCR analysis of Pitx2 in the mesenchyme of Tgfbr2^fl/fl;Wnt1-Cre (closed columns) and Tgfbr2^fl/fl control (open column) mice after FGF9 or BSA treatment. *, p < 0.05. Error bars, S.D.