TABLE 1.

Summary of APP antibodies and their specificity

General characteristics of the APP antibodies and their specificity tested by immunocytochemical staining of 14 DIV wild type and APP null primary hippocampal cultures fixed with 4% PFA are shown. The origins of the antibodies can be found under “Experimental Procedures.” ICC, immunocytochemistry; mAb, monoclonal antibody; pAb, polyclonal antibody; aa, amino acids.

Antibody	Species	Epitope	ICC specificity
Y188	Rabbit mAb	YENPTY motif	High
A8967	Rabbit pAb	46–60 aa	No
Ab15272	Rabbit pAb	44–62 aa	No
APPc	Rabbit pAb	C terminus	No
22C11	Mouse mAb	66–81 aa	No
4G8	Mouse mAb	Aβ 17–24 aa	No
APP 39184	Mouse mAb	61–77 aa	No
APP 39180	Mouse mAb	573–596 aa	No
5A3/1G7	Mouse mAb	N terminus	Low