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Schematic representation of the pyruvate-metabolic pathways in S. aureus. Pyruvate is metabolized to acetyl-CoA via PDHC, which is formed by four protein subunits (PdhA, -B, -C, and -D) or reduced to lactate or to butandiole via acetolactate and acetoine. Acetyl-CoA is either funnelled into the tricarboxylic acid cycle, used for various biosynthetic pathways, or hydrolyzed to form free acetate.
