FIGURE 4.

α-Tocopherol is not able to protect against CQ toxicity. A, α-TTP KO mice were fed a control diet (a) or α-tocopherol excess diet (b). Liver tissues were collected 24 h after single oral administration of 100 mg/kg CQ. Sections were stained with hematoxylin-eosin. The arrows indicate hepatocyte degeneration and microvesicular formation. Scale bars = 25 μm. B, cell viabilities of McARH7777 and McA-TTP cells were measured 24 h and 36 h following treatment with 100 μm CQ with/without the addition 50 μm α-tocopherol.