Skip to main content
. Author manuscript; available in PMC: 2012 Jan 30.
Published in final edited form as: Clin Cancer Res. 2008 Oct 1;14(19):6005–6013. doi: 10.1158/1078-0432.CCR-08-0216

Figure 4.

Figure 4

Relationships between CIMP, MSI and CIN. (A) A Venn diagram depicts that the majority of CIMP-positive tumors have MSI and low-degree chromosomal aberrations. The 12 CIMP-positive samples in the light blue circle were determined using MethyLight assay and the five designated methylation markers. The eight samples within the red circle and the 44 samples in the pink circle are tumors with low- and high-degree CIN, respectively. There are 11 MSI samples in the light green circle. Four samples that do not belong to any circle have a near diploid genome, are unmethylated at any of the five markers, and are microsatellite stable. (B) Distribution of promoter methylation status and LOH at 15 tumor suppressor gene loci in the 60 primary colorectal tumors. The gene names and their corresponding chromosome location are indicated on the top of the diagram. Tumor samples are organized and displayed based on the number of methylated loci. CIMP-positive samples (determined using MethyLight assay) were indicated with asterisk. Tumors of CIMP-positive and high-degree CIN features were labeled with arrows. The tumor suppressor gene promoter methylation and LOH status are color coded and indicated.