Table 2.
Assessment of population stratification adjustment on GWAS hit association results for CBCS stratified by race.
| Race | SNP | Gene or region | Risk allele | N cases | N controls | Age and offset | Age, PC1, and offset | Age, PC1, PC1*SNP, and offset | p-Value for PC1*SNP interaction | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p-Value | OR (95% CI) | p-Value | OR (95% CI) | p-Value | |||||||
| European American | rs2981582 | FGFR2 | C | 1204 | 1089 | 1.31 (1.15,1.48) | <0.0001 | 1.31 (1.15,1.48) | <0.0001 | 1.36 (0.77,2.40) | 0.29 | 0.88 |
| rs1219648 | A | 1203 | 1089 | 1.31 (1.15,1.48) | <0.0001 | 1.31 (1.16,1.48) | <0.0001 | 1.93 (1.12,3.36) | 0.02 | 0.15 | ||
| rs2420946 | C | 1202 | 1086 | 1.30 (1.15,1.37) | <0.0001 | 1.30 (1.15,1.48) | <0.0001 | 1.54 (0.96,2.49) | 0.07 | 0.47 | ||
| rs11200014 | G | 1204 | 1089 | 1.31 (1.15,1.48) | <0.0001 | 1.31 (1.15,1.48) | <0.0001 | 0.97 (0.58,1.62) | 0.90 | 0.24 | ||
| rs2981579 | C | 1204 | 1089 | 1.33 (1.18,1.51) | <0.0001 | 1.33 (1.18,1.51) | <0.0001 | 1.22 (0.79,1.90) | 0.37 | 0.70 | ||
| rs2162540 | A | 1202 | 1089 | 1.31 (1.15,1.48) | <0.0001 | 1.31 (1.15,1.48) | <0.0001 | 1.56 (0.96,2.51) | 0.07 | 0.46 | ||
| rs3135718 | A | 1204 | 1089 | 1.31 (1.15,1.48) | <0.0001 | 1.31 (1.16,1.48) | <0.0001 | 1.56 (0.97,2.53) | 0.07 | 0.45 | ||
| rs2936870 | C | 1204 | 1089 | 1.30 (1.15,1.47) | <0.0001 | 1.30 (1.15,1.47) | <0.0001 | 1.59 (0.98,2.57) | 0.06 | 0.40 | ||
| rs2912774 | C | 1202 | 1087 | 1.30 (1.15,1.47) | <0.0001 | 1.30 (1.15,1.47) | <0.0001 | 1.60 (0.99,2.59) | 0.06 | 0.38 | ||
| rs1896395 | C | 1204 | 1089 | 1.86 (0.53,6.48) | 0.33 | 2.07 (0.59,7.20) | 0.25 | 2.53 (0.18,36.03) | 0.49 | 0.51 | ||
| rs13281615 | 8q24 | A | 1198 | 1088 | 1.11 (0.98,1.26) | 0.09 | 1.11 (0.98,1.26) | 0.09 | 1.16 (0.64,2.10) | 0.63 | 0.89 | |
| African American | rs2981582 | FGFR2 | C | 742 | 658 | 1.19 (1.02,1.39) | 0.03 | 1.19 (1.02,1.39) | 0.03 | 1.64 (0.97,2.76) | 0.06 | 0.21 |
| rs1219648 | A | 742 | 658 | 1.19 (1.02,1.39) | 0.03 | 1.19 (1.02,1.39) | 0.03 | 1.62 (0.99,2.66) | 0.06 | 0.20 | ||
| rs2420946 | C | 742 | 658 | 1.17 (1.00,1.37) | 0.05 | 1.17 (1.00,1.37) | 0.05 | 1.84 (1.11,3.05) | 0.02 | 0.06 | ||
| rs11200014 | G | 742 | 658 | 1.04 (0.86,1.26) | 0.69 | 1.05 (0.86,1.27) | 0.64 | 1.16 (0.71,1.91) | 0.55 | 0.65 | ||
| rs2981579 | C | 742 | 658 | 1.22 (1.04,1.42) | 0.01 | 1.22 (1.04,1.42) | 0.01 | 1.84 (1.10,3.07) | 0.02 | 0.09 | ||
| rs2162540 | A | 742 | 657 | 1.23 (1.05,1.44) | 0.01 | 1.23 (1.05,1.44) | 0.01 | 1.93 (1.16,3.22) | 0.01 | 0.06 | ||
| rs3135718 | A | 742 | 656 | 1.26 (1.08,1.46) | 0.003 | 1.26 (1.08,1.46) | 0.003 | 1.73 (1.04,2.89) | 0.04 | 0.20 | ||
| rs2936870 | C | 741 | 658 | 1.27 (1.09,1.48) | 0.003 | 1.27 (1.08,1.48) | 0.003 | 1.82 (1.08,3.08) | 0.02 | 0.15 | ||
| rs2912774 | C | 742 | 657 | 1.27 (1.09,1.49) | 0.003 | 1.27 (1.09,1.49) | 0.003 | 1.86 (1.10,3.14) | 0.02 | 0.14 | ||
| rs1896395 | C | 742 | 658 | 1.01 (0.84,1.23) | 0.89 | 1.01 (0.83,1.23) | 0.93 | 1.18 (0.50,2.78) | 0.71 | 0.72 | ||
| rs13281615 | 8q24 | A | 736 | 658 | 1.00 (0.86,1.18) | 0.97 | 1.00 (0.86,1.18) | 0.96 | 0.50 (0.28,0.88) | 0.02 | 0.01 | |