Table 2.
Summary of sex, diet, and PyMT by epistasis interactions affecting the weight and adiposity traits.
| Trait | Sex × epistasis | Diet × epistasis | PyMT × epistasis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Males | Females | Differ | Total | Control | High-fat | Differ | Total | PyMT | PyMT+ | Differ | |
| 3W | 6 | 2 | 1 | 3 | 7 | 2 | 1 | 4 | ||||
| 6W | 18 | 10 | 1 | 7 | 28 | 9 | 12 | 7 | 24 | 7 | 8 | 9 |
| 9W | 11 | 3 | 3 | 5 | 21 | 10 | 5 | 6 | 14 | 5 | 6 | 3 |
| SW | 13 | 4 | 5 | 4 | 16 | 4 | 3 | 9 | 19 | 2 | 7 | 10 |
| LIV | 8 | 3 | 2 | 3 | 12 | 3 | 2 | 7 | 10 | 1 | 7 | 2 |
| PLV | 1 | 0 | 1 | 0 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| PF7 | 11 | 3 | 5 | 3 | 11 | 3 | 4 | 4 | 7 | 5 | 2 | 0 |
| LM7 | 6 | 2 | 1 | 3 | 9 | 2 | 3 | 4 | 10 | 3 | 1 | 1 |
| FS | 23 | 11 | 5 | 7 | 13 | 5 | 3 | 3 | 20 | 3 | 6 | 11 |
| PFS | 8 | 2 | 2 | 4 | 4 | 1 | 2 | 1 | 4 | 0 | 4 | 0 |
| FP | 4 | 3 | 1 | 0 | 5 | 1 | 3 | 1 | 5 | 0 | 2 | 3 |
| PFP | 2 | 0 | 2 | 0 | 2 | 0 | 2 | 0 | 3 | 0 | 2 | 1 |
| LMS | 5 | 0 | 3 | 2 | 7 | 1 | 2 | 4 | 12 | 2 | 7 | 3 |
| Total | 116 | 43 | 32 | 41 | 130 | 39 | 44 | 47 | 135 | 30 | 55 | 50 |
Shown are the total numbers of interactions of sex, diet, and PyMT with overall epistasis (Total) and the numbers of epistatic interactions that are significant only in males or in females (sex by epistasis interactions), only in the control or high-fat diets (diet by epistasis interactions), only in the mice with (PyMT+) or without (PyMT−) the PyMT gene (PyMT by epistasis interactions), or that exhibit differential effects (Differ) in the two sex, diet, or PyMT groups.