Table A2.
Penetrance functions for one-locus recessive main effect models.
| One-locus recessive models | ||||||||
|---|---|---|---|---|---|---|---|---|
| OR | Models (#) | MAF = 0.2 | Models (#) | MAF = 0.4 | ||||
| AA | Aa | Aa | AA | Aa | Aa | |||
| 1.2 | (1) h2 = 1.06% | 0.016766 | 0.01396 | 0.01396 | (2) h2 = 1.09% | 0.016766 | 0.01396 | 0.01396 |
| 1.4 | (3) h2 = 1.088% | 0.019766 | 0.014118 | 0.014118 | (4) h2 = 1.077% | 0.018366 | 0.013118 | 0.013118 |
| 1.6 | (5) h2 = 1.027% | 0.020966 | 0.0131 | 0.0131 | (6) h2 = 1.05% | 0.019366 | 0.0121 | 0.0121 |
| 1.8 | (7) h2 = 1.028% | 0.023126 | 0.012847 | 0.012847 | (8) h2 = 1.08% | 0.021126 | 0.01173 | 0.01173 |
| 2.0 | (9) h2 = 1.068% | 0.02607 | 0.013031 | 0.013031 | (10) h2 = 1.077% | 0.0218 | 0.010891 | 0.010891 |
| 2.0 | (11) h2 = 5.006% | 0.120806 | 0.06029 | 0.06029 | (12) h2 = 5.03% | 0.100806 | 0.05029 | 0.05029 |
| 2.5 | (13) h2 = 5.002% | 0.140558 | 0.05622 | 0.05622 | (14) h2 = 5.003% | 0.105106 | 0.04204 | 0.04204 |
| 3.0 | (15) h2 = 5.08% | 0.015791 | 0.052618 | 0.052618 | (16) h2 = 5.038% | 0.106906 | 0.035595 | 0.035595 |
(#), Model numbers; OR, odds ratio; MAF, minor allele frequency; h2, heritability; values in the center of the table represent the probability of disease given the genotype.