Table A7.

Four-way penetrance function for large dataset.

		CC				Cc		cc
		BB	Bb	bb	BB	Bb	bb	BB	Bb	bb
	AA	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003
DD	Aa	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003
	aa	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003
	AA	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003
Dd	Aa	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003
	aa	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003	0.003
		(1)			(2)				(3)
	AA	0.055	0.055	0.055	0.095	0.095	0.095	0.01	0.0634	0.01
dd	Aa	0.055	0.055	0.055	0.095	0.095	0.095	0.0634	0.01	0.0634
	aa	0.01	0.01	0.01	0.0095	0.0095	0.0095	0.01	0.0634	0.01

MAF = 0.5; (1) h² = 0.9%; (2) h² = 2.0%; (3) h² = 2.0%.

Total h² = 5.0%.

(#), Embedded penetrance functions for the 2 one-locus and the XOR two-locus models respectively are shaded in gray; h², heritability scores; MAF, minor allele frequency; values in the center of the table represent the probability of disease given the genotype.