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. Author manuscript; available in PMC: 2012 Jan 30.
Published in final edited form as: Mol Cell. 2009 May 14;34(4):473–484. doi: 10.1016/j.molcel.2009.04.021

Figure 5.

Figure 5

Structure of subcomplex II of the PAN regulatory particle. (A) Structure of the nucleotidase domain of PAN. The α/β fold and the helical domain are shown in magenta and cyan, respectively. ADP is bound to the hinge region between these two domains. (B) The nucleotidase domain of PAN is structurally similar to the AAA+ ATPases of ClpX and HslU. Shown here is a stereo comparison of the relevant structures. (C) ADP is coordinated by residues from both the α/β fold and the helical domain. (D) Model of the nucleotidase ring. The atomic coordinates of the PAN nucleotidase were superimposed onto those of the HslU hexamer (Bochtler et al., 2000; Sousa et al., 2000) to generate the nucleotidase ring. Two perpendicular views are shown on the left. The surface representations are shown on the right. Note the highly acidic proximal face.