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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Free Radic Biol Med. 2011 Nov 12;52(3):699–704. doi: 10.1016/j.freeradbiomed.2011.11.004

Figure 4.

Figure 4

Ultrastructural examination of cases of AD immunodecorated with the antibody to the fluorophore (17 nm gold). At lower magnification, structures labeled (solid arrows) are indeed consistent with GVD seen at light level (A). Normal mitochondria (open arrows in A) as well as paired helical filaments (B) remain unstained, while GVD structures are intensely and specifically labeled (B, C). Even using a post-embed staining method, lipofuscin remains unstained by the fluorophore antibody (D). Scale bar for A,B = 1 μm; C,D = 0.5 μm.