Table 2.
Genotype Association of COMT SNP rs165774
| Sample | Genotype Counts | p-value* | ||
|---|---|---|---|---|
| AA (%) | AG (%) | GG (%) | ||
| control | 39 (16.25) | 98 (40.83) | 103 (42.92) | |
| Nicotine dependence | 21 (14.38) | 51 (34.93) | 74 (50.69) | 0.330 |
| Odds ratio | 1 | 0.966 | 1.334 | 0.205† |
| p-value | 1.000 | 0.700 | ||
| Opiate dependence | 13 (11.11) | 47 (40.17) | 57 (48.72) | 0.363 |
| Odds ratio | 1 | 1.439 | 1.660 | 0.172† |
| p-value | 0.626 | 0.300 | ||
| Alcohol dependence | 18 (7.96) | 97 (42.92) | 111(49.12) | 0.022 |
| Odds ratio | 1 | 2.146 | 2.336 | 0.023† |
| p-value | 0.029 | 0.012 | ||
* p-value determined by Pearson's χ2 test (DF = 2)
† p-value determined using the extended Mantel-Haenszel test for trend (DF = 1)