Table 1.
Analysis of the clinical data for 423 hospitalized patients
| general | severely | critically | fatal | p value | Total | |
|---|---|---|---|---|---|---|
| Case number (n) | 189 | 197 | 28 | 9 | 423 | |
| Number of cases in which a pathogen was detected (n) | 85(45.0%) | 71(36%) | 16(57.1%) | 5(55.6%) | 0.076 | 177(41.8%) |
| Age*(Years)① | 3.045 ± 2.102 | 2.546 ± 1.730 | 1.893 ± 1.397 | 2.056 ± 1.509 | 0.003 | |
| Gender(male, n) | 125(66.1%) | 114(57.9%) | 25(89.3%) | 8(88.9%) | 0.003 | 272(64.3%) |
| Region(from countryside, n) | 116(61.4%) | 124(62.9%) | 23(82.1%) | 5(55.6%) | 0.185 | 268(63.4%) |
| Time from onset to hospitalization(d)① | 4.44 ± 1.37 | 3.89 ± 1.26 | 3.92 ± 1.02 | 3.81 ± 0.96 | 0.000 | |
| Duration of hospitalization(d)② | 8.85 ± 2.46 | 11.63 ± 5.04 | 49.51 ± 33.20 | 4.55 ± 1.91 | 0.000 | |
| WBC > 12 × 109 (n) | 86(45.5%) | 121(61.4%) | 27(96.4%) | 8(88.9%) | 0.000 | 242(57.2%) |
| Duration of initial fever(d)② | 5.24 ± 1.54 | 6.33 ± 1.94 | 8.38 ± 6.42 | 6.42 ± 2.25 | 0.012 | |
| Highest fever temperature (°C)③ | 38.76 ± 0.46 | 38.846 ± 0.62 | 39.206 ± 0.51 | 39.07 ± 0.41 | 0.032 | |
| Hand or foot rash (n) | 173(91.5%) | 183(92.9%) | 23(82.1%) | 6(66.7%) | 0.017 | 385(91.0%) |
| Oral rash (n) | 121(64.0%) | 118(59.9) | 17(74.6) | 4(44.4%) | 0.608 | 260(61.5%) |
| Buttock rash (n) | 76(40.2%) | 81(41.1%) | 6(21.4%) | 2(22.2%) | 0.159 | 165(39.0) |
| No rash (n) | 2(7.1%) | 1(11.1%) | 0.000 | 3(0.7%) | ||
| EV71 (n) | 24(12.7%) | 47(23.9%) | 13(46.4%) | 5(55.6%) | 0.000 | 89(21%) |
| CA16 (n) | 49(25.9%) | 18(9.1%) | 1©(3.6%) | 0 | 0.000 | 68(16.1%) |
| Other enteroviruses (n) | 12(6.3%) | 6(3%) | 2(7.1%) | 0 | 0.369 | 20(4.7%) |
| Patients with neurological dysfunction upon discharge (n) | 0 | 2®(1%) | 11(39.3%) | 0.000 | 13(3.1%) |
①There is statistically significant difference between general group and the other 3 groups but no difference in comparison to the other 3 groups. ②There is statistically significant difference between all groups. ③There is no difference between general groups and severely group or critically group and fatal group, but there is significant difference between each one of the former and the latter two groups. # There was no repeat counting in calculating the distribution of disease types. When neurogenic pulmonary edema or shock and brain stem encephalitis coexisted in the same patient, the former was counted. When neurogenic shock and pulmonary edema coexisted, pulmonary edema was counted. §The denominator of the fraction represents the cases examined, whereas the numerator represents the number of patients with this abnormality. ¤Among the 5 fatal cases, 2 died of neurogenic pulmonary edema, 2 died of shock and 1 patient was declared brain-dead