Table 4.
Additional genotyping at 17q12 to localize association signal
| SNPa | Variationb | Genec | Cased | Controle | Multiplicativef | Regressiong |
|---|---|---|---|---|---|---|
| rs12601930 | (T/C) | PPP1R1B | 0.188 | 0.179 | 5.59 × 10-1 1.061 (0.876-1.284) |
5.73 × 10-1 0.944 (0.771-1.155) |
| rs9532 | (T/C) | PPP1R1B | 0.001 | 0.001 | 1.00 1.007 (0.063-16.118) |
9.54 × 10-1 1.085 (0.066-17.84) |
| rs1877031 | (T/C) | STARD3 | 0.346 | 0.401 | 2.96 × 10-3 0.792 (0.679-0.924) |
1.96 × 10-1 1.419 (0.835-2.412) |
| rs876493 | (T/C) | PNMT | 0.266 | 0.305 | 2.37 × 10-2 0.825 (0.700-0.973) |
4.50 × 10-1 1.111 (0.846-1.460) |
| rs2941504 | (A/G) | PERLD1 | 0.305 | 0.359 | 9.56 × 10-6 0.745 (0.654-0.848) |
NA |
| rs1136201 | (G/A) | ERBB2 | 0.097 | 0.123 | 3.03 × 10-2 0.768 (0.606-0.974) |
5.89 × 10-1 0.930 (0.715-1.210) |
| rs1058808 | (G/C) | ERBB2 | 0.325 | 0.389 | 7.81 × 10-4 0.756 (0.644-0.889) |
9.00 × 10-2 0.652 (0.398-1.069) |
The genotyped SNPs are sorted according to chromosomal position at 17q12 (not shown).
a) The SNP rsID; b) The polymorphism in the format (minor allele/ancestral allele); c) Gene name; d) & e) Minor allele frequencies in case and control samples respectively; f) P value obtained from a Fisher's test for a multiplicative genetic model together with allelic odds ratio and 95% confidence interval calculated from allele counts using the minor allele as the reference; g) P value obtained from a logistic regression analysis of allelic association using PERLD1 SNP rs2941504 as a covariate together with odds ratio and 95% confidence interval from the regression.