Table 1.

 Model fit for alternative models: basic age-period-cohort model, then model extended with screening variables and with screening variables and hormone treatment using either shared or separate modelling of hormone treatment types

Model	Deviance	Degrees of freedom	P values
			Last variables added	Over-dispersion	Non-linear period effects
Age-period-cohort	27 994	25 319	<0.001	<0.001	<0.001
Age-period-cohort+screening variables	27 527	25 316	<0.001	0.035	<0.001
Age-period-cohort+screening variables+hormone treatment	27 459	25 315	<0.001	0.082	0.074
Age-period-cohort+screening variables+hormone treatment including types*	27 459	25 314	0.647	0.082	0.140

*Grouped as oestrogens alone or oestrogen-progestogen combinations.