Figure 3.

a, Representative plethysmographic recordings from a female RTT patient (modified from ref. 22) and an Mecp2^Stop/y-hGFAPcreT2 mouse and control. The two middle traces are from the same Mecp2^Stop/y-hGFAPcreT2 mouse before and 62 days after TAM treatment (Supplementary Fig. 7c, trace 3). b, Respiratory irregularity scores and apnoea rates for male mice. c, Same as in b except for female mice. Mice showing at least 1 apnoea per hour were considered for apnoea rates. All error bars indicate s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001. NS, not significant. The number of mice analysed is indicated above each bar.