Table 3.
Generalized Estimating Equation Analysis of Disease Risk Associated With Sibling Age at Follow-up Intervals Relative to Proband Dementia With Lewy Bodies (DLB) Statusa
| Variable | Odds Ratio (95% Confidence Interval) | P Value |
|---|---|---|
| Probable DLB | ||
| Sibling age | 1.05 (1.01–1.09) | .01 |
| Proband DLB status | 2.29 (1.04–5.04) | .04 |
| Possible DLB | ||
| Sibling age | 1.06 (1.04–1.09) | <.001 |
| Proband DLB status | 1.51 (0.97–2.34) | .07 |
| Cognitive fluctuations | ||
| Sibling age | 1.01 (0.98–1.03) | .68 |
| Proband DLB status | 1.55 (0.95–2.53) | .08 |
| Visual hallucinations | ||
| Sibling age | 1.04 (1.00–1.07) | .04 |
| Proband DLB status | 2.32 (1.16–4.64) | .02 |
| Parkinsonism | ||
| Sibling age | 1.08 (1.04–1.12) | <.001 |
| Proband DLB status | 1.30 (0.67–2.50) | .44 |
a
All models are adjusted for age, sex, and education. Probands with Alzheimer disease were used as the reference.