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. Author manuscript; available in PMC: 2013 Jan 27.
Published in final edited form as: Immunity. 2011 Dec 29;36(1):79–91. doi: 10.1016/j.immuni.2011.11.013

Figure 4. Ligand specificity of MHC-independent αβTCRs.

Figure 4

(A) αβT cells. Proliferative responses were measured by CFSE dye dilution of primary αβT cells from Quad-deficient.Bcl2 (Quad-KO.Bcl2) mice against various stimulators. Data are representative of two experiments.

(B) CD155 epitopes recognized by MHC-independent TCRs. Schematic representation of chimeric mouse-human CD155 molecules are displayed (left). IL-2 response of TCR-transduced 4G4 cells (4×104) stimulated with 293T cells transfected with cDNA encoding various CD155 chimeric constructs (right). Each data point represents the mean (±SEM) of triplicate culture. Data are representative of two experiments.

(C) IL-2 response of TCR transduced 4G4 cells (1×105) stimulated with either native or heat denatured recombinant mCD155 protein. Each data point represents the mean (±SEM) of triplicate culture. Data are representative of three independent experiments.