Table 3.
Effect of Treatment of High Fat/Streptozotocin Diabetic Rats with enalapril, candoxatril or ilepatril on Soleus Muscle Diacylglycerol and Ceramide levels
| Determination | Control (9) | Diabetic (9) | Diabetic + enalapril (8) | Diabetic + candoxatril (9) | Diabetic + ilepatril (8) |
|---|---|---|---|---|---|
| Diacylglycerol (nmol/mg wet wt) | 4.1 ± 0.6 | 7.6 ± 0.5 | 4.3 ± 1.1 | 4.6 ± 1.6 | 4.3 ± 0.9 |
| Ceramide (pmol/mg wet wt) | 295 ± 16 | 715 ± 65a | 409 ± 37 | 314 ± 26b | 272 ± 17b |
Data are presented as the mean ± S.E.M.
a
P < 0.05 compared to control;
b
p < 0.05 compared to diabetic. Parentheses indicate the number of experimental animals.