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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Pharmacol Ther. 2011 Nov 17;133(2):205–217. doi: 10.1016/j.pharmthera.2011.10.007

Figure 3. Risperidone concentration-response curve for wash-resistant inhibition of specific [3H]5-HT binding to the h5-HT7 receptor.

Figure 3

HEK-293-h5-HT7 cells were suspended in isotonic buffer and exposed to buffer (control) or varying concentrations of risperidone, a drug that displayed full inactivating properties (see Fig. 1). After the drug washout procedure, the cells were incubated with 2 nM [3H]5-HT; nonspecific binding was determined with the addition of 10μM clozapine. These results are from (Knight et al., 2009) and are the means ± S.E.M. of three independent experiments performed in triplicate.