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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Pharmacol Ther. 2011 Nov 17;133(2):205–217. doi: 10.1016/j.pharmthera.2011.10.007

Figure 5. Correlation between the reactivation potencies (log EC50, ordinate) and affinities (log Ki, abscissa) of competitive antagonists at the h5-HT7 receptor.

Figure 5

The high correlation observed (r2=0.95) indicates that the reactivation of risperidone-inactivated h5-HT7 receptors is due to the binding of the reactivating drugs to the orthosteric binding site of the h5-HT7 receptor despite the presence of wash-resistant risperidone bound to the orthosteric site. These results are from (Teitler et al., 2010) and are the mean±S.E.M. of three experiments performed in triplicate.