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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Pharmacol Ther. 2011 Nov 17;133(2):205–217. doi: 10.1016/j.pharmthera.2011.10.007

Figure 7. Correlation between competitive antagonists' reactivation potencies (pEC50, ordinate) and potencies to inhibit 5-HT-stimulated cAMP production (pKb, abscissa) in rat cortical astrocytes.

Figure 7

The correlation is highly significant (r2=0.92, p=0.01); this indicates that the reversal of risperidone's inactivating effect is occurring through the r5-HT7 receptor orthosteric binding site. These results are from (Smith et al., 2010) and are the means±S.E.M. of three independent experiments performed in triplicate.