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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Biomaterials. 2012 Jan 14;33(10):2952–2960. doi: 10.1016/j.biomaterials.2011.12.043

Figure 1. Synthesis of fullerene[60] serinol malonate pentakis-adduct – PromoFluor-633 conjugate (6).

Figure 1

(i) Hünig’s base, in dry CH2Cl2, −20 °C → RT, 6 h. (ii) C60, CBr4, DBU, 4 h. (iii) 3, CBr4, base P1-t-Bu, 24 h. (iv) 1M HCl in dioxane: water = 99:1, RT, 48 h. (v) PF-633 carboxylic acid, EDC, HOBt Hydrate, MES buffer, 30 min.