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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Exp Neurol. 2011 Nov 4;233(1):333–341. doi: 10.1016/j.expneurol.2011.10.025

Figure 1.

Figure 1

Co-injections of LPS and cystine cause focal intraspinal inflammation with concurrent activation of system Xc-. (A) Real-time PCR analysis of mRNA obtained via laser capture microdissection from control (PBS) or LPS+cystine microinjection sites reveals focal increases in xCT mRNA expression at sites of CNS macrophage activation. (B–D) A qualitative comparison of F4/80 labeling (for CNS macrophages) at sites injected with cystine (B), LPS (C) or LPS+cystine reveals the enhanced pro-inflammatory effects of LPS+cystine injections. (*indicates central canal;*** p<0.001; scale bar = 100 μm; n=5–8/group)