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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Exp Neurol. 2011 Nov 4;233(1):333–341. doi: 10.1016/j.expneurol.2011.10.025

Figure 3.

Figure 3

Intraspinal activation of system xc- is neurotoxic. Neurons were quantified in the spinal cord ventral horn 3 days after injecting cystine, LPS or LPS+cystine. (A–C) Significant neuron loss was evident nearby the site of LPS+cystine injection (ANOVA; *p<0.05 vs. LPS alone). Immunohistochemical labeling of Huc/HuD (AF546 with DAPI counterstain) reveals differences in numbers of spinal cord ventral horn neurons after injecting LPS (B) or LPS+cystine (C). (* = central canal; scale bar = 100μm; n=5–8per group (n=150–200neurons counted on contralateral (intact) side per animal).