Figure 8.

Model of the interrelationships of taurine and oxidative/nitrosative stress in Schwann cells in diabetes.

High intracellular glucose increases intracellular sorbitol content and nitrosative stress. Both deplete taurine by reducing taurine uptake. Taurine depletion in turn increases oxidative stress and iNOS and nNOS expression, further increasing nitrosative stress resulting in a feed-forward cycle.