Table 4. Alcoholism-related differences in connectivity were specific to fronto-cerebellar circuits.

Post hoc tests of connectivity in circuits other than fronto-parietal are reported to serve as a control analysis. Connectivity for each region pair is expressed as a regression coefficient with 95% confidence interval shown in parentheses. The seed regions were selected because they showed finger tapping activation in patients but not in controls. The target regions were selected because they showed positive functional connectivity with the corresponding seed on average over all subjects regardless of group (p<0.001 uncorrected).

Region 1 (Seed)	Region 2 (Target)	Controls	Patients	Difference, Controls - Patients	Region 2 MNI Coords (mm)
Right Premotor	PreSMA	0.13 (0.09,0.17)	0.11 (0.05,0.17)	0.02 (−0.05,0.09), p=0.53	9, 5, 54
Right Prefrontal	Med. Dorsal Prefrontal	0.14 (0.10,0.18)	0.12 (0.06,0.18)	0.03 (−0.04,0.09), p=0.44	3, 36, 42
	Left Parietal	0.05 (0.02,0.07)	0.05 (0.01,0.09)	0.00 (−0.05,0.04), p=0.84	−45, −51, 33
Right Parietal	L Cerebellum VI	0.11 (0.02,0.20)	0.15 (0.07,0.22)	−0.04 (−0.15,0.07), p=0.48	−27, −48, −33
	Cerebellar Vermis	0.11 (0.02,0.20)	0.14 (0.07,0.21)	−0.03 (−0.14,0.08), p=0.61	−3, −63, −18
Left Temporal	R Cerebellum VI	0.08 (0.03,0.13)	0.08 (0.03,0.13)	0.00 (−0.07,0.06), p=0.91	24, −60, −27
	L Cerebellum VI	0.09 (0.03,0.14)	0.09 (0.04,0.14)	0.00 (−0.07,0.06), p=0.90	−24, −57, −24