(A) A representative intracellular Ca2+ concentration response in an astrocyte stimulated with glutamate (10 μM) after perfusion with KB-R7943 (30 μM), presented as change in Fura-2 fluorescence ratio. (B) Effects of KB-R7943 (30 μM) on gabapentin (GBP, 100 μM) and riluzole (Ril, 0.1–1 μM)-induced enhancement of glutamate-induced intracellular Fura-2 fluorescence ratio response. Each box represents the 25th, 50th, and 75th percentiles of Fura-2 fluorescence ratio response. Number under each box represents sample size. *P<0.05 vs. without KB-R7943.