Fig. 1.

BMP-7, but not BMP-6, inhibits TGF-β-induced invasion in M-IV, but not in M-II. a–d Spheroids were allowed to invade collagen in the presence of BMP-7 (100 ng/ml), TGF-β (5 ng/ml) or TGF-β & BMP-7. a Pictures of representative spheroids of M-II. b Quantification of invasion of M-II experiments shown in (a). c Pictures of representative spheroids of M-IV. d Quantification of invasion of M-IV experiments shown in (c). e Spheroids of M-IV were allowed to invade collagen in the presence of BMP-6 (100 ng/ml), TGFβ (5 ng/ml) or TGF-β & BMP-6. Pictures of representative spheroids are shown. f Quantification of invasion of experiments shown in (e). The results are expressed as mean ± S.D. of at least three spheroids per condition. One representative out of three independent experiments is shown. Significance *** p < 0.001