Table 1.

Potential candidates for new antituberculosis drugs

Drug candidate	Mechanism	Attributes
TMC-207	Targeting of ATP synthase	Efficacy proven in animal model and clinical trial; novel pharmaceutical target
PNU-100480	Linezolid-analog, targeting ribosome	Novel pharmaceutical target
SQ-109	Ethambutol-analogue, targeting cell-wall synthesis	Efficacy proven in animal model
OPC-67683 and PA-824	Prodrug; bioreactive activation	Potentially effective against latent tuberculosis

Abbreviation: ATP, adenosine triphosphate.