TABLE 1.
Human lipodystrophy genes (26) with their apparent homologs in Arabidopsis
| Human gene | Protein function | Candidate Arabidopsis homolog(s)a |
| AGPAT2 | LPAT, synthesis of phosphatidic acid | At1g80950; At1g51260; At3g57650; At3g18850; At1g75020; At4g30580 |
| BSCL2 | Seipin, role in LD morphology, number, size | At5g16460; At1g29760; At2g34380 |
| CAV1 | Caveolin 1, formation of membrane microdomains | No compelling homologc |
| LMNA | Lamin A, nuclear lamina protein subunit | No compelling homologc |
| PPARG | PPAR γ- transcription factor regulates lipid synthesis | No compelling homologc |
| AKT2 | Protein kinase B | At3g08730; At3g08720; At5g04510b; At310540b |
| ZMPSTE24 | Zinc metalloprotease; processing of lamin subunits | At4g01320 |
| CGI-58 | ABHD5; coactivator of ATGL, also has LPAT activity | At4g24160 |
| LIPA | Lysosomal acid lipase; hydrolyzes cholesteryl esters and TAGs | At5g14180; At2g15230 |
a
Best match by WU-BLAST against the Arabidopsis genome at TAIR (www.arabidopsis.org).
b
Contains Pleckstrin homology domains and has phosphoinositide-3-dependent kinase activity.
c
e value > 5.0.