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. 2012 Feb;53(2):215–226. doi: 10.1194/jlr.R021436

TABLE 2.

TAG “compartmentation” genes in yeast and their apparent homologs in Arabidopsis.

Yeast gene Protein function Candidate Arabidopsis homolog(s)a
ADE8 Phosphoribosyl-glycinamide transformylase (de novo purine biosynthesis) At1g31220
ADE12 Adenylosuccinate synthase (purine biosynthesis) At3g57610
ANP1 Alpha-1,6 mannosyltransferase transmembrane subunit No compelling homologb
CHC1 Clathrin heavy chain subunit At3g08530; At3g11130
CNM67 Spindle pole body component required for proper nuclear migration No compelling homologb
ERD1 Membrane protein; retention of lumenal ER proteins At5g35730; At2g32295
EST3 Telomerase component No compelling homologb
KEM1 Component of cytoplasmic processing (P) bodies involved in mRNA decay At1g75660; At5g42540; At5g42540; At1g54490
MDM20 Non-catalytic subunit of the NatB N-terminal acetyltransferase No compelling homologb
NEM1 Catalytic subunit of Nem1p-Spo7p phosphatase; regulates P-lipid synthesis At5g46410; AT5G11860; AT4G18140 (SCP1-like P-ases)
OST4 Subunit of the oligosaccharyltransferase complex of the ER lumen No compelling homologb
PAF1 Component of the Paf1p complex; modulates the activity of RNA polymerases At1g79730
ROX3 Subunit of the RNA polymerase II mediator complex No compelling homologb
SPO7 Regulatory subunit of Nem1p-Spo7p phosphatase No compelling homologb
SSD1 Translational repressor with a role in cell wall polar growth and integrity At1g77680; At2g17510
TPD3 Subunit A of protein phosphatase 2A (PP2A); required for cell morphogenesis At3g25800; At1g13320; At1g25490
VMA6 Integral membrane subunit of vacuolar H -ATPase (V-ATPase) At3g28715; At3g28710
VPS16 Vacuole protein sorting subunit; essential for membrane docking and fusion At2g38020
VPS66 Cytoplasmic protein of unknown function involved in vacuolar protein sorting No compelling homologb
YLR404W Seipin, lipid droplet size, homology to human BSCL2 involved in lipodystrophy At5g16460; At1g29760; At2g34380

Yeast genes selected below are from genetic screens for abnormal LD morphology found by both (23, 124).

a

Twelve of the 20 selected yeast genes have putative Arabidopsis homologs [identified by WU-BLAST against the Arabidopsis genome at TAIR (www.arabidopsis.org)].

b

e value > 5.0.