Figure 7.

Mrc2 reduces the severity of interstitial fibrosis in Col4α3^−/− mice with hereditary nephritis. Col4α3^−/− Mrc2^+/+ and Col4α3^−/− Mrc2^−/− male mice on a C57BL/6 background underwent a unilateral nephrectomy at 2 months of age and were sacrificed at age 4 months (n=5 –7 per group). The graphs show significantly higher total kidney collagen levels (A) and serum BUN levels (C) and urinary protein/creatinine ratios (D) in the Col4α3^−/− Mrc2^−/− mice. (B) The mean glomerular matrix areas, measured as the percentage of glomerular tuft area stained with methenamine silver, were not significantly different. The bar graphs are mean ± SD. *P<0.05.