Table 1.

Proposed Pediatric Diffuse Lung Disease Classification

Disorders more prevalent in infancy	Specific disorders in disorders prevalent in infancy	Other categories	Specific disorders in other category
Diffuse developmental disorders	ACDMPV, congenital alveolar dysplasia	Disorders of the normal host	Infection, hypersensitivity, aspiration
Growth abnormalities	Pulmonary hypoplasia, chronic neonatal lung disease of prematurity, trisomy 12, congenital heart disease	Disorders of systemic disease	Metabolic disease, collagen vascular and autoimmune
Pulmonary interstitial glycogenosis (PIG)	Patchy PIG with growth abnormalitiesDiffuse PIG without growth abnormalities	Disorders of the immune compromised	Infection, lymphocytic disorders, transplant-related
Neuroendocrine cell hyperplasia of infancy (NEHI)		Disorders masquerading as ILD	Lymphatic abnormalities, pulmonary arterial or vein abnormalities
Surfactant dysfunction disorders	Surfactant proteins B and C; ABCA3, TTF1, lysinuric protein intolerance, undefined	Unclassified	Poor quality biopsy