Species								Rodent: single dose in solution
			Rat			Mouse			Human
Dose	(mg/kg)		1	10		1	10		10 mg		Human: BID
AUC inf	(uM hr)		0.6	11.4		1.2	18.2				More than dose prop exposures
C max	(uM)		0.1	3.7		0.5	7.6		0.47		­ in oral t1/2 suggest change in clearance mechanisms
C min	(uM)			0.03			0.01		0.3
C max/ C min ratio				123			760		1.54		Much lower Cmax/Cmin ratio in human
T max	(hr)		1	0.5 - 1		0.5	0.5 - 1		4 - 6
			1 mg/kg (iv)			1 mg/kg (iv)
Vd ss	(L/kg)			8 - 9			8 - 9		9 - 11
Cl p	(L/hr/kg)			4.15			3.81		0.16		Much lower (estimated) clearance in human. Renal elimination in all species
GFR	(L/hr/kg)			0.31			0.84		0.11		Clp >> GFR  suggests active elimination
t 1/2	(hr)			4			3		60 - 80