Figure 9. The 5′ flanking region of the GABA_AR ε gene exhibits highly conserved transcription factor binding sites in rat, mouse, and human that are consistent with activity-dependent gene expression.

Rat, mouse and human GABA_AR ε genes were analyzed for putative transcription factor binding sites using the NCBI program MULAN. Within the first 5 kb of the 5′ flanking region of this gene, we identified a putative binding site for the Serum Response Factor (SRF) and the Cyclic AMP Response Element Binding protein (CREB) which are 96 and 95% identical, respectively, among the rat, mouse and human genes. Starting and ending basepair location relative to the 5 kb 5′ flanking region are listed to the left and right of each sequence.