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. 2012 Feb;97(2):189–192. doi: 10.3324/haematol.2011.054031

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Figure 3. — Model of transferrin-dependent regulation of hepcidin expression in hypotransferrinemic mice. Hepcidin expression is regulated by the activity of the stores-and erythroid-regulators. Stores-regulator activity, mediated by transferrin (Tf) and BMP6, stimulates hepcidin expression in a hemojuvelin-dependent manner. Erythroid-regulator activity, possibly mediated by Tmprss6, Gdf15 and Twsg1, inhibits hemojuvelin-dependent hepcidin expression. Erythroid-regulator activity in hpx mice can be diminished by RBC transfusions or transferrin (TF) administration.