Table 1.
Cardiac function before, during and after IR injury.
| Baseline | Ischemia (30 min) | Reperfusion (10 min) | |
|---|---|---|---|
| dLVP/dtmax (mmHg/s) | |||
| IR10 | 2342±228 | 1342±136 | |
| RanIR | 2449±133 | 2406±151# | |
| dLVP/dtmin (mmHg/s) | |||
| IR10 | 2052±129 | 955±106 | |
| RanIR | 1923±185 | 1971±166# | |
| Systolic-diastolic LVP (mmHg) | |||
| IR10 | 88±4 | 38±5 | |
| RanIR | 90±4 | 57±7# | |
| Diastolic LVP (mmHg) | |||
| I30 | 0±0 | 3±1 | |
| RanI30 | 0±0 | 1±1# | |
| IR10 | 0±0 | 5±2 | |
| RanIR | 0±0 | 0±0# | |
| Coronary flow (ml/min) | |||
| IR10 | 15.9±0.7 | 14.8±0.6 | |
| RanIR | 15.2±1.1 | 15.3±1.1 | |
| Heart rate (beats/min) | |||
| IR10 | 227±4 | 228±2 | |
| RanIR | 233±5 | 226±2 |
LVP = Left ventricular pressure
I30 = 30 min of global ischemia
IR10 = 30 min of global ischemia + 10 min reperfusion
RanI30 = 10 μM Ran given 1 min before I30
RanIR = 10 μM Ran given 1 min before IR10
#
indicates p<0.05 for RanI30 or RanIR vs. I30 or IR10